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CAY10571

Cayman Chemical Item Number 10010400

(CAS 152121-46-5)

CAY10571 (CAS 152121-46-5)

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Description

Pyridinylimidazoles, often termed CSAIDs, are a class of anti-inflammatory compounds that inhibit eicosanoid production and suppress the synthesis of cytokines in human monocytes.1 Because of its high specificity, one predominant pyridinylimidazole, SB203580, is frequently used to inhibit p38 MAPK, the tyrosine kinase activated by environmental stresses and inflammatory cytokines.2 CAY10571 is an analog of SB203580. It inhibits IL-1 production in the human monocytic cell line THP with an IC50 value of 0.20 µM and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity with an IC50 value of 0.03 µM.3,4 CAY105571 also inhibits 5-lipoxygenase production in RBL-1 cells with an IC50 value of 24 µM.3

1 Lee, J.C., Laydon, J.T., McDonnell, P.C., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372(22) 739-746 (1994).

2 Cuenda, A., Rouse, J., Doza, Y.N., et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364 229-233 (1995).

3 Gallagher, T.F., Fier-Thompson, S.M., Garigipati, R.S., et al. 2,4,5-triarylimidazole inhibitors of IL-1 biosynthesis. Bioorg Med Chem Lett 5(11) 1171-1176 (1995).

4 Gallagher, T.F., Seibel, G.L., Kassis, S., et al. Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinase. Bioorg Med Chem 5(1) 49-64 (1997).

Formal Name 4-​[5-​(4-​fluorophenyl)-​2-​[4-​(methylsulfonyl)phenyl]-​1H-​imidazol-​4-​yl]-​pyridine
CAS Number 152121-46-5
Molecular Formula C21H16FN3O2S
Formula Weight 393.4
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Fc1ccc(cc1)​c1nc([nH]​c1c1ccncc1)​c1ccc(cc1)​S(=O)​(=O)​C

Background Reading

Gallagher, T.F., Seibel, G.L., Kassis, S., et al. Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinase. Bioorg Med Chem 5(1) 49-64 (1997).

Gallagher, T.F., Fier-Thompson, S.M., Garigipati, R.S., et al. 2,4,5-triarylimidazole inhibitors of IL-1 biosynthesis. Bioorg Med Chem Lett 5(11) 1171-1176 (1995).

Lee, J.C., Laydon, J.T., McDonnell, P.C., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372(22) 739-746 (1994).

Cuenda, A., Rouse, J., Doza, Y.N., et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364 229-233 (1995).

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CAY10571 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $37.00 $0.00
10 mg $70.00 $0.00
25 mg $167.00 $0.00
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Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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SB 203580

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