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SP 600125

Cayman Chemical Item Number 10010466

1PMV; Pyrazolanthrone; NSC 75890 (CAS 129-56-6)

SP 600125 (CAS 129-56-6)

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Description

The three isoforms of c-Jun N-terminal kinase (JNK) are members of the MAP kinase superfamily that induce the expression of immediate-early genes in response to specific stress and inflammatory signals. Through these actions, the JNK enzymes modulate cell proliferation, apoptosis, differentiation, and autophagy. SP 600125 is a potent and reversible inhibitor of JNK1, 2, and 3, with an IC50 value of 0.11 μM.1 It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.1 SP 600125 also prevents apoptosis in many cell types, including B-cells,2 and inhibits autophagy in HeLa cells.3

1 Bennett, B.L., Sasaki, D.T., Murray, B.W., et al. SP600125, an anthrapyrazolone inhibitor of jun N-terminal kinase. Proc Natl Acad Sci USA 98(24) 13681-13686 (2001).

2 Kim, Y.S., Park, G.B., Lee, H., et al. Cross-linking of B7-H1 on EBV-transformed B cells induces apoptosis through reactive oxygen species production, JNK signaling activation, and fasL expression. J Immunol 181 6158-6169 (2008).

3 Zhang, Y., Wu, Y., Cheng, Y., et al. Fas-mediated autophagy requires JNK activation in HeLa cells. Biochem Biophys Res Commun 377 1205-1210 (2008).

Synonyms
  • 1PMV
  • Pyrazolanthrone
  • NSC 75890
Formal Name anthra[1,​9-​cd]pyrazol-​6(2H)-​one
CAS Number 129-56-6
Molecular Formula C14H8N2O
Formula Weight 220.2
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=c1c2ccccc2c2n[nH]​c3cccc1c23

Background Reading

Bennett, B.L., Sasaki, D.T., Murray, B.W., et al. SP600125, an anthrapyrazolone inhibitor of jun N-terminal kinase. Proc Natl Acad Sci USA 98(24) 13681-13686 (2001).

Lawrence, M.C., Jivan, A., Shao, C., et al. The roles of MAPKs in disease. Cell Res 18 436-442 (2008).

Zhang, Y., Wu, Y., Cheng, Y., et al. Fas-mediated autophagy requires JNK activation in HeLa cells. Biochem Biophys Res Commun 377 1205-1210 (2008).
Size Price Quantity Subtotal
5 mg $37.00 $0.00
10 mg $70.00 $0.00
25 mg $167.00 $0.00
50 mg $296.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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