Cayman Chemical | 15-Lipoxygenase Inhibitor 1 | Description • 15-LO Inhibitor 1 (CAS 928853-86-5)

10010468 15-Lipoxygenase Inhibitor 1

15-LO Inhibitor 1 (CAS 928853-86-5)

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• See more Inhibitors; Lipoxygenase; Atherosclerosis; Inflammation

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Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.¹ The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.² 15-LO inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC₅₀ value of 18 µM.³ The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.³

1 Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annu Rev Biophys Biomol Struct 25 431-459 (1996).

2 Chanez, P., Bonnans, C., Chavis, C., et al. 15-Lipoxygenase. A janus enzyme?. Am J Respir Cell Mol Biol 27 655-658 (2002).

3 Bakavoli, M., Nikpour, M., Rahimizadeh, M., et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem 15 2120-2126 (2007).

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Pricing updated 2010-03-17.
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