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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

15-Lipoxygenase Inhibitor 1 Exclusive

Cayman Chemical Item Number 10010468

15-LO Inhibitor 1 (CAS 928853-86-5)

15-Lipoxygenase Inhibitor 1 (CAS 928853-86-5)

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Description

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.1 The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.2 15-LO inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.3 The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.3

1 Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annu Rev Biophys Biomol Struct 25 431-459 (1996).

2 Chanez, P., Bonnans, C., Chavis, C., et al. 15-Lipoxygenase. A janus enzyme? Am J Respir Cell Mol Biol 27 655-658 (2002).

3 Bakavoli, M., Nikpour, M., Rahimizadeh, M., et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem 15 2120-2126 (2007).

Synonyms
  • 15-LO Inhibitor 1
Formal Name 4-​methyl-​2-​(4-​methylpiperazinyl)pyrimido[4,​5-​b]benzothiazine
CAS Number 928853-86-5
Molecular Formula C16H19N5S
Formula Weight 313.4
Formulation A solution in chloroform
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Cc1nc(nc2Sc3ccccc3Nc12)​N1CCNCC1

Background Reading

Chanez, P., Bonnans, C., Chavis, C., et al. 15-Lipoxygenase. A janus enzyme? Am J Respir Cell Mol Biol 27 655-658 (2002).

Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annu Rev Biophys Biomol Struct 25 431-459 (1996).

Bakavoli, M., Nikpour, M., Rahimizadeh, M., et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem 15 2120-2126 (2007).
Size Price Quantity Subtotal
500 µg $22.00 $0.00
1 mg $42.00 $0.00
5 mg $176.00 $0.00
10 mg $308.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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