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5(Z),14(Z)-Eicosadienoic Acid Exclusive

Cayman Chemical Item Number 10010484

(CAS 122055-58-7)

5(Z),14(Z)-Eicosadienoic Acid (CAS 122055-58-7)

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Description

5(Z),14(Z)-Eicosadienoic Acid is a novel ω-6 C20:2 fatty acid. The more common 11(Z),14(Z)-eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM)1 and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).2 Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators. The physiological effects of 5(Z),14(Z)-eicosadienoic acid are unstudied.

1 Mizushina, Y., Dairaku, I., Yanaka, N., et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie 89 581-590 (2007).

2 Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

3 Irmisch, G., Schläfke, D., Gierow, W., et al. Fatty acids and sleep in depressed inpatients. Prostaglandins Leukot Essent Fatty Acids 76 1-7 (2007).

Formal Name (5Z,​14Z)-​eicosadienoic acid
CAS Number 122055-58-7
Molecular Formula C20H36O2
Formula Weight 308.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\CCCCCCC/C=C\CCCC(=O)​O

Background Reading

Mizushina, Y., Dairaku, I., Yanaka, N., et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie 89 581-590 (2007).

Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

Irmisch, G., Schläfke, D., Gierow, W., et al. Fatty acids and sleep in depressed inpatients. Prostaglandins Leukot Essent Fatty Acids 76 1-7 (2007).

Size Price Quantity Subtotal
100 µg $65.00 $0.00
500 µg $293.00 $0.00
1 mg $520.00 $0.00
5 mg $2,275.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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