10010484 5(Z),14(Z)-Eicosadienoic Acid
(CAS 122055-58-7)
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5(Z),14(Z)-Eicosadienoic Acid is a novel ω-6 C20:2 fatty acid. The more common 11(Z),14(Z)-eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM)1 and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).2 Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators. The physiological effects of 5(Z),14(Z)-eicosadienoic acid are unstudied.
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1
Mizushina, Y., Dairaku, I., Yanaka, N., et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie 89 581-590 (2007).
2
Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).
3
Irmisch, G., Schläfke, D., Gierow, W., et al. Fatty acids and sleep in depressed inpatients. Prostaglandins Leukot Essent Fatty Acids 76 1-7 (2007).
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Pricing updated 2010-03-19.
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