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14,15-EE-8(Z)-E Exclusive

Cayman Chemical Item Number 10010486

14,15-Epoxyeicosa-8(Z)-enoic Acid (CAS 519038-93-8)

14,15-EE-8(Z)-E (CAS 519038-93-8)

See more	Oxylipins (227) Endocrinology (337) Hypertension (97) Vascular Disease (115)

Description

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.¹ 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.^2,3

1 Fleming, I. Epoxyeicosatrienoic acids, cell signaling and angiogenesis. Prostaglandins Other Lipid Mediat 82 60-67 (2007).

2 Gauthier, K.M., Falck, J.R., Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. Pharmacol Res 49 515-524 (2004).

3 Falck, J.R., Krishna, U.M., Reddy, Y.K., et al. Comparison of vasodilatory properties of 14,15-EET analogs: Structural requirements for dilation. Am J Physiol Heart Circ Physiol 284 337-349 (2003).

Synonyms	14,15-Epoxyeicosa-8(Z)-enoic Acid
Formal Name	13[(2R,3S)-3-pentyloxiranyl]-8Z-tridecenoic acid
CAS Number	519038-93-8
Molecular Formula	C₂₀H₃₆O₃
Formula Weight	324.5
Formulation	A solution in ethanol
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@H]1O[C@H]1CCCC/C=C\CCCCCCC(=O)O

Background Reading

Fleming, I. Epoxyeicosatrienoic acids, cell signaling and angiogenesis. Prostaglandins Other Lipid Mediat 82 60-67 (2007).

Gauthier, K.M., Falck, J.R., Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. Pharmacol Res 49 515-524 (2004).

Falck, J.R., Krishna, U.M., Reddy, Y.K., et al. Comparison of vasodilatory properties of 14,15-EET analogs: Structural requirements for dilation. Am J Physiol Heart Circ Physiol 284 337-349 (2003).

Size	Price	Quantity	Subtotal
25 µg	$36.00		$0.00
50 µg	$68.00		$0.00
100 µg	$130.00		$0.00
500 µg	$576.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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