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Vialinin A

Cayman Chemical Item Number 10010519

Terrestrin A (CAS 858134-23-3)

Vialinin A (CAS 858134-23-3)

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Description

Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris 1 and T. vialis.2 Terphenyls, in general, are recognized as strong antioxidants.3 Vialinin A potently inhibits the release of TNF-α (IC50 = 0.09 nM) and IL-4 (IC50 = 2.8 nM), as well as β-hexosaminidase and CCL2 (MCP-1) from IgE-stimulated RBL-2H3 mast cells.4 Vialinin A does not significantly increase lactate dehydrogenase release from RBL-2H3 mast cells, suggesting low cytotoxicity.4

1 Radulovic, N., Quang, D.N., Hashimoto, T., et al. Terrestrins A-G: P-teraphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochem 66 1052-1059 (2005).

2 Xie, C., Koshino, H., Esumi, Y., et al. Vialinin A, a novel 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger from an edible mushroom in china. Biosci Biotechnol Biochem 69(12) 2326-2332 (2005).

3 Liu, J. Natural terphenyls: Developments since 1877. Chem Rev 106 2209-2223 (2006).

4 Onose, J., Xie, C., Ye, Y.Q., et al. Vialinin A, a novel potent inhibitor of TNF-a production from RBL-2H3 cells. Biol Pharm Bull 31(5) 831-833 (2008).

Synonyms
  • Terrestrin A
Formal Name 4,​4”,​5’,​6’-​tetrahydroxy[1,​1’:4’,​1”-​terphenyl]-​2’,​3’-​diyl ester benzeneacetic acid
CAS Number 858134-23-3
Molecular Formula C34H26O8
Formula Weight 562.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1ccc(cc1)​c1c(OC(=O)​Cc2ccccc2)​c(OC(=O)​Cc2ccccc2)​c(c2ccc(O)​cc2)​c(O)​c1O

Background Reading

Onose, J., Xie, C., Ye, Y.Q., et al. Vialinin A, a novel potent inhibitor of TNF-a production from RBL-2H3 cells. Biol Pharm Bull 31(5) 831-833 (2008).

Xie, C., Koshino, H., Esumi, Y., et al. Vialinin A, a novel 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger from an edible mushroom in china. Biosci Biotechnol Biochem 69(12) 2326-2332 (2005).

Liu, J. Natural terphenyls: Developments since 1877. Chem Rev 106 2209-2223 (2006).

Radulovic, N., Quang, D.N., Hashimoto, T., et al. Terrestrins A-G: P-teraphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochem 66 1052-1059 (2005).

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Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
25 mg $805.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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