See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

O-Arachidonoyl Glycidol Exclusive

Cayman Chemical Item Number 10010547

(CAS 439146-24-4)

O-Arachidonoyl Glycidol (CAS 439146-24-4)

See more

Description

2-Arachidonoyl glycerol (2-AG) is an endogenous ligand that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity.1 Levels of this endocannabinoid are regulated by hydrolysis to glycerol and arachidonic acid by the enzyme monoacylglycerol lipase. O-Arachidonoyl glycidol is a 2-AG analog that blocks 2-oleoyl glycerol hydrolysis in the cytosolic and membrane fractions of rat cerebella with IC50 values of 4.5 and 19 µM, respectively.1 O-Arachidonoyl glycidol inhibits fatty acid amide hydrolase-catalyzed hydrolysis of arachidonoyl ethanolamide (AEA) in the membrane fraction of rat cerebella with an IC50 value of 12 µM.1

1 Cisneros, J.A., Vandevoorde, S., Ortega-Gutiérrez, S., et al. Structure-activity relationship of a series of inhibitiors of monoacylglycerol hydrolysis-comparison with effects upon fatty acid amide hydrolase. J Med Chem 50 5012-5023 (2007).

Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraenoic acid,​ oxiranylmethyl ester
CAS Number 439146-24-4
Molecular Formula C23H36O3
Formula Weight 360.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​OCC1CO1

Background Reading

Cisneros, J.A., Vandevoorde, S., Ortega-Gutiérrez, S., et al. Structure-activity relationship of a series of inhibitiors of monoacylglycerol hydrolysis-comparison with effects upon fatty acid amide hydrolase. J Med Chem 50 5012-5023 (2007).
Size Price Quantity Subtotal
5 mg $66.00 $0.00
10 mg $125.00 $0.00
50 mg $528.00 $0.00
100 mg $924.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Arachidonoyl Ethanolamide
D-erythro-Sphingosine C-15
N-Arachidonyl Maleimide
URB597
URB937 Exclusive
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?