10010547 O-Arachidonoyl Glycidol
(CAS 439146-24-4)
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2-Arachidonoyl glycerol (2-AG) is an endogenous ligand that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity.1 Levels of this endocannabinoid are regulated by hydrolysis to glycerol and arachidonic acid by the enzyme monoacylglycerol lipase. O-Arachidonoyl glycidol is a 2-AG analog that blocks 2-oleoyl glycerol hydrolysis in the cytosolic and membrane fractions of rat cerebella with IC50 values of 4.5 and 19 µM, respectively.1 O-Arachidonoyl glycidol inhibits fatty acid amide hydrolase-catalyzed hydrolysis of arachidonoyl ethanolamide (AEA) in the membrane fraction of rat cerebella with an IC50 value of 12 µM.1
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1
Cisneros, J.A., Vandevoorde, S., Ortega-Gutiérrez, S., et al. Structure-activity relationship of a series of inhibitiors of monoacylglycerol hydrolysis-comparison with effects upon fatty acid amide hydrolase. J Med Chem 50 5012-5023 (2007).
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Pricing updated 2010-03-13.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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