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Acenocoumarol

Cayman Chemical Item Number 10010569

Sinthrome®; G-23350; Nicoumalone; Acenocoumarin; Sintrom® (CAS 152-72-7)

Acenocoumarol (CAS 152-72-7)

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Description

Acenocoumarol is an analog of the oral anticoagulant warfarin that functions by inhibiting vitamin K epoxide reductase, an enzyme that has a critical role in enabling blood coagulation.1 It is a brief-acting compound with a half-life of about eight hours in plasma, which is four times shorter than that of warfarin.2

1 Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet 44(12) 1227-1246 (2005).

2 Thijssen, H.H., Flinois, J., and Beaune, P.H. Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab Dispos 28(11) 1284-1290 (2000).

Synonyms
  • Sinthrome®
  • G-23350
  • Nicoumalone
  • Acenocoumarin
  • Sintrom®
Formal Name 4-​hydroxy-​3-​[1-​(4-​nitrophenyl)-​3-​oxobutyl]-​2H-​1-​benzopyran-​2-​one
CAS Number 152-72-7
Molecular Formula C19H15NO6
Formula Weight 353.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(=O)​CC(c1ccc(cc1)​[N+]​(=O)​[O-]​)​c1c(=O)​oc2ccccc2c1O

Background Reading

Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet 44(12) 1227-1246 (2005).

Thijssen, H.H., Flinois, J., and Beaune, P.H. Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab Dispos 28(11) 1284-1290 (2000).
Size Price Quantity Subtotal
10 mg $41.00 $0.00
50 mg $185.00 $0.00
100 mg $328.00 $0.00
250 mg $718.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(R)-(+)-Acenocoumarol
(S)-(−)-Acenocoumarol
(−)-Warfarin
(+)-Warfarin
(±)-Warfarin
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