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Wortmannin

Cayman Chemical Item Number 10010591

KY 12420 (CAS 19545-26-7)

Wortmannin (CAS 19545-26-7)

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Description

By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from Drosophila, murine, and human differ in sensitivity to wortmannin (IC50 = 5, 50, 450 nM, respectively).1 Wortmannin also inhibits polo-like kinase 1 (IC50 = 24 nM)2 and polo-like kinase 3 (IC50 = 49 nM)3, as well as mTOR, DNA-PK, PI4K, MLCK, and p38 MAPK at 50 to 100 fold higher concentrations than that needed for PI3K inhibition.

1 Fruman, D.A., Meyers, R.E., and Cantley, L.C. Phosphoinositide kinases. Annu Rev Biochem 67 481-507 (2008).

2 Liu, Y., Shreder, K.R., Gai, W., et al. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem Biol 12 99-107 (2005).

3 Liu, Y., Jiang, N., Wu, J., et al. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem 282(4) 2505-2511 (2007).

Synonyms
  • KY 12420
Formal Name 11-​(acetyloxy)-​1S,​6bR,​7,​8,​9aS,​10,​11R,​11bR-​octahydro-​1-​(methoxymethyl)-​9a,​11b-​dimethyl-​3H-​furo[4,​3,​2-​de]indeno[4,​5-​h]-​2-​benzopyran-​3,​6,​9-​trione
CAS Number 19545-26-7
Molecular Formula C23H24O8
Formula Weight 428.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC[C@H]​1OC(=O)​c2coc3C(=O)​C4=C([C@H]​(OC(=O)​C)​C[C@]​5(C)​C(=O)​CCC45)​[C@]​1(C)​c23

Background Reading

Fruman, D.A., Meyers, R.E., and Cantley, L.C. Phosphoinositide kinases. Annu Rev Biochem 67 481-507 (2008).

Liu, Y., Shreder, K.R., Gai, W., et al. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem Biol 12 99-107 (2005).

Liu, Y., Jiang, N., Wu, J., et al. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem 282(4) 2505-2511 (2007).

Wortmannin is available in the following screening library:

Size Price Quantity Subtotal
1 mg $40.00 $0.00
5 mg $160.00 $0.00
10 mg $240.00 $0.00
25 mg $450.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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