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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

AG-1296

Cayman Chemical Item Number 10010592

Tyrphostin AG-1296 (CAS 146535-11-7)

AG-1296 (CAS 146535-11-7)

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Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas.1 AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 vaule of about 0.4 µM both in vitro and in cells (Swiss 3T3 cells).2 It inhibits ligand-stimulated DNA synthesis in PDGF receptor and stem cell factor (SCF)/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 µM, respectively. 2 Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.2

1 Levitzki, A., and Gazit, A. Tyrosine kinase inhibition: An approach to drug development. Science 267(5205) 1782-1788 (1995).

2 Kovalenko, M., Gazit, A., Böhmer, A., et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54 6106-6114 (1994).

Synonyms
  • Tyrphostin AG-1296
Formal Name 6,​7-​dimethoxy-​2-​phenyl-​quinoxaline
CAS Number 146535-11-7
Molecular Formula C16H14N2O2
Formula Weight 266.3
Formulation A crystalline solid
Purity >98%
λmax 233, 264, 367 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1cc2nc(cnc2cc1OC)​c1ccccc1

Background Reading

Levitzki, A., and Gazit, A. Tyrosine kinase inhibition: An approach to drug development. Science 267(5205) 1782-1788 (1995).

Kovalenko, M., Gazit, A., Böhmer, A., et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54 6106-6114 (1994).

AG-1296 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $21.00 $0.00
5 mg $95.00 $0.00
10 mg $168.00 $0.00
25 mg $368.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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