13,14-dihydro-15-keto Prostaglandin E2-d4

13,14-dihydro-15-keto Prostaglandin E₂-d₄ Exclusive

Cayman Chemical Item Number 10010606

13,14-dh-15-keto PGE₂-d₄

Description

13,14-dihydro-15-keto Prostaglandin E₂-d₄ (13,14-dh-15-keto PGE₂-d₄) contains four deuterium atoms at the 3, 3 · , 4, and 4 · positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-keto PGE₂ by GC- or LC-mass spectrometry (MS). 10-100 pg/ml.^1,2 It undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dh-15-keto PGE₂ is about 9 minutes.¹ In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE₂ biosynthesis.^3,4

1 Bothwell, W., Verburg, M., Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E₁ and E₂: An indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther 220 229-235 (1982).

2 Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

3 Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

4 Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

Synonyms

13,14-dh-15-keto PGE2-d4

Formal Name

9,15-dioxo-11α-hydroxy-prost-5Z-en-1-oic-3,3,4,4-d4 acid

Molecular Formula

C₂₀H₂₈D₄O₅

Formula Weight

356.5

Formulation

A solution in methyl acetate

Purity

≥99% deuterated forms (d1-d4)

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CCCCCC(=O)CC[C@H]1C(O)CC(=O)C1C/C=C\CCCC(=O)O

Background Reading

Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man. J Biol Chem 246 6713-6721 (1971).

Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

Bothwell, W., Verburg, M., Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E₁ and E₂: An indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther 220 229-235 (1982).

Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

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25 µg 
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50 µg 
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100 µg 
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500 µg 
$1,280.00

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13,14-dihydro-15-keto Prostaglandin E₂-d₄ Exclusive