CB2 Receptor Polyclonal FITC Antibody

CB₂ Receptor Polyclonal FITC Antibody

Cayman Chemical Item Number 10010712

Cannabinoid Receptor 2

Description

Antigen: human CB₂ receptor sequence amino acids 20-33 (NPMKDYMILSGPQK) · Host: rabbit · Application(s): FC, IF, and WB; other applications not tested · The central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors are G protein-coupled receptors (GPCRs) that bind the active component of cannabis, Δ⁹-tetrahydrocannabinol, as well as anandamide which is an endogenous CB receptor ligand. This antibody has been raised against a sequence between the N-terminal and the first transmembrane domain of the protein of the human CB₂ receptor.¹ Conserved amino acids between the CB₁ and CB₂ receptors in this region are minimal thereby preventing cross-reactivity of this antibody with the CB₁ receptor.² Human and mouse CB₂ receptors exhibit 82% homology at the amino acid level over the complete protein.² The CB₂ receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells.¹

1 Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 61-65 (1993).

2 Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB₂ peripheral cannabinoid receptor. Biochim Biophys Acta 1307 132-136 (1996).

Synonyms

Cannabinoid Receptor 2

Formulation

Peptide affinity-purified IgG

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human CB2 receptor	+
Mouse CB2 receptor	+

Background Reading

Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 61-65 (1993).

Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB₂ peripheral cannabinoid receptor. Biochim Biophys Acta 1307 132-136 (1996).