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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)-Lisofylline

Cayman Chemical Item Number 10010785

CT-1501R; BL 194; LSF (CAS 6493-06-7)

(±)-Lisofylline (CAS 6493-06-7)

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Description

(±)-Lisofylline (LSF) is a potent anti-inflammatory agent in which only the (−) optical isomer is biologically active.1,2 LSF inhibits the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.3 LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits IL-12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.4,1

1 Yang, Z., Chen, M., Ellett, J.D., et al. Inflammatory blockade improves human pancreatic islet function and viability. Am J Transplant 5 475-483 (2005).

2 Wyska, E., Pekala, E., and Szymura-Oleksiak, J. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality 18 644-651 (2006).

3 Rice, G.C., Brown, P.A., Nelson, R.J., et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc Natl Acad Sci USA 91 3857-3861 (1994).

4 Yang, Z., Chen, M., Wu, R., et al. The anti-inflammatory compound lisofylline prevents type I diabetes in non-obese diabetic mice. Diabetologia 45 1307-1314 (2002).

Synonyms
  • CT-1501R
  • BL 194
  • LSF
Formal Name 3,​7-​dihydro-​1-​(5-​hydroxyhexyl)-​3,​7-​dimethyl-​1H-​purine-​2,​6-​dione
CAS Number 6493-06-7
Molecular Formula C13H20N4O3
Formula Weight 280.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(O)​CCCCn1c(=O)​c2n(C)​cnc2n(C)​c1=O

Background Reading

Yang, Z., Chen, M., Ellett, J.D., et al. Inflammatory blockade improves human pancreatic islet function and viability. Am J Transplant 5 475-483 (2005).

Rice, G.C., Brown, P.A., Nelson, R.J., et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc Natl Acad Sci USA 91 3857-3861 (1994).

Yang, Z., Chen, M., Wu, R., et al. The anti-inflammatory compound lisofylline prevents type I diabetes in non-obese diabetic mice. Diabetologia 45 1307-1314 (2002).
Size Price Quantity Subtotal
10 mg $43.00 $0.00
25 mg $102.00 $0.00
50 mg $194.00 $0.00
250 mg $753.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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