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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide Exclusive

Cayman Chemical Item Number 10010809

16-phenoxy tetranor PGF2α cyclopropyl methyl amide

16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide

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Description

The actions of many clinical F-series prostaglandins, including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the prostaglandin F2α (FP) receptor.1,2,3 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide (16-phenoxy tetranor PGF2α cyclopropyl methyl amide) is an analog of PGF2α containing a 16-phenoxy group on the lower (ω) side chain and a cyclopropyl methyl amide at the C-1 position. There are no published reports on the biological activity of 16-phenoxy tetranor PGF2α cyclopropyl methyl amide.

1 Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79 1193-1226 (1999).

2 Resul, B., Stjernschantz, J., Selén, G., et al. Structure-activity relationships and receptor profiles of some ocular hypotensive prostanoids. Surv Ophthalmol 41 S47-S52 (1997).

3 Clark, A.F., and Yorio, T. Ophthalmic drug discovery. Nature 2 448-459 (2003).

Synonyms
  • 16-phenoxy tetranor PGF2α cyclopropyl methyl amide
Formal Name 9α,​11α,​15R-​trihydroxy-​16-​phenoxy-​17,​18,​19,​20-​tetranor-​prosta-​5Z,​13E-​dien-​1-​cyclopropyl methyl amide
Molecular Formula C26H37NO5
Formula Weight 443.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(CCC/C=C\CC1C(O)​CC(O)​[C@@H]​1\C=C\C(O)​COc1ccccc1)​NCC1CC1

Background Reading

Resul, B., Stjernschantz, J., Selén, G., et al. Structure-activity relationships and receptor profiles of some ocular hypotensive prostanoids. Surv Ophthalmol 41 S47-S52 (1997).

Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79 1193-1226 (1999).

Clark, A.F., and Yorio, T. Ophthalmic drug discovery. Nature 2 448-459 (2003).
Size Price Quantity Subtotal
1 mg $55.00 $0.00
5 mg $248.00 $0.00
10 mg $440.00 $0.00
50 mg $1,925.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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