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DL-Propargyl Glycine (hydrochloride)

Cayman Chemical Item Number 10010948

PAG

DL-Propargyl Glycine (hydrochloride)

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Description

Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.1 DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.2 At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.3,4,5

1 Li, L., and Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air? Trends Pharmacol Sci 29(2) 84-90 (2007).

2 Mok, Y.P., Atan, M.S.B.M., Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 143 881-889 (2004).

3 Bhatia, M., Sidhapuriwala, J.N., Ng, S.W., et al. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. J Cell Mol Med 12(2) 580-590 (2008).

4 Bhatia, M., Sidhapuriwala, J., Moochhala, S.M., et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br J Pharmacol 145 141-144 (2005).

5 Collin, M., Anuar, F.B.M., Murch, O., et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br J Pharmacol 146 498-505 (2005).

Synonyms
  • PAG
Formal Name 2-​amino-​4-​pentynoic acid,​ monohydrochloride
Molecular Formula C5H7NO2 · HCl
Formula Weight 149.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(CC#C)​C(=O)​O

Background Reading

Bhatia, M., Sidhapuriwala, J., Moochhala, S.M., et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br J Pharmacol 145 141-144 (2005).

Bhatia, M., Sidhapuriwala, J.N., Ng, S.W., et al. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. J Cell Mol Med 12(2) 580-590 (2008).

Mok, Y.P., Atan, M.S.B.M., Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 143 881-889 (2004).

Li, L., and Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air? Trends Pharmacol Sci 29(2) 84-90 (2007).

Collin, M., Anuar, F.B.M., Murch, O., et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br J Pharmacol 146 498-505 (2005).

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Size Price Quantity Subtotal
1 mg $12.00 $0.00
5 mg $54.00 $0.00
10 mg $96.00 $0.00
50 mg $420.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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