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KT 5823

Cayman Chemical Item Number 10010965

(CAS 126643-37-6)

KT 5823 (CAS 126643-37-6)

See more	Inhibitors (546) Cell Biology (303) Nitric Oxide (101) Signal Transduction (328)

Description

The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of PKG (in vitro IC₅₀ = 234 nM).¹ KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.² KT 5823 is a weak inhibitor of PKC (K_i = 4 µM) and PKA (K_i >10 µM).¹

1 Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32 377-397 (1992).

2 Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275(43) 33536-33541 (2000).

Formal Name	2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
CAS Number	126643-37-6
Molecular Formula	C₂₉H₂₅N₃O₅
Formula Weight	495.5
Formulation	A neat oil
Purity	≥95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COC(=O)[C@@]1(OC)C[C@H]2O[C@@]1(C)n1c3ccccc3c3c4CN(C)C(=O)c4c4c5ccccc5n2c4c13

Background Reading

Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32 377-397 (1992).

Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275(43) 33536-33541 (2000).

Size	Price	Quantity	Subtotal
25 µg	$28.00		$0.00
50 µg	$53.00		$0.00
100 µg	$101.00		$0.00
250 µg	$224.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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