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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

W123 Exclusive

Cayman Chemical Item Number 10010992

W123

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Description

Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPγS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization.1 It has a Ki value of 0.69 μM when assessed by SEW2871-induced activation of S1P1.1 Its specificity for other S1P receptor subtypes remains to be determined.

1 Wei, S.H., Rosen, H., Matheu, M.P., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 6(12) 1228-1235 (2005).

Formal Name 3-​(2-​(3-​hexylphenylamino)-​2-​oxoethylamino)propanoic acid
Molecular Formula C17H26N2O3
Formula Weight 306.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​CCNCC(=O)​Nc1cccc(CC2CCCCC2)​c1

Background Reading

Wei, S.H., Rosen, H., Matheu, M.P., et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 6(12) 1228-1235 (2005).
Size Price Quantity Subtotal
1 mg $64.00 $0.00
5 mg $288.00 $0.00
10 mg $512.00 $0.00
25 mg $1,120.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

azido-FTY720
FTY720
SEW2871

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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