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4-phenyl-5-methyl-1,2,3-Thiadiazole

Cayman Chemical Item Number 10011049

NSC 358739 (CAS 64273-28-5)

4-phenyl-5-methyl-1,2,3-Thiadiazole (CAS 64273-28-5)

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Description

Cytochrome P450 (CYP450) enzymes are a superfamily of oxidative catalysts important in the biosynthesis and metabolism of a wide range of endogenous molecules as well as the metabolism of xenobiotics. For example, CYP2B4 metabolizes substituted amines, CYP2E1 metabolizes various alcohols and halogenated alkenes, and CYP1A2 catalyzes the oxygenation of aromatic compounds and polycyclic hydrocarbons. 4-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1 at a concentration of 100 µM that does not inactivate CYP1A2.1 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-5-methyl-1,2,3-thiadiazole, are also commonly used as fungicides, herbicides, and plant growth regulators.

1 Babu, B.R., and Vaz, A.D.N. 1,2,3-thiadiazole: A novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry 36 7209-7216 (1997).

Synonyms
  • NSC 358739
Formal Name 5-​methyl-​4-​phenyl-​1,​2,​3-​thiadiazole
CAS Number 64273-28-5
Molecular Formula C9H8N2S
Formula Weight 176.2
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Cc1snnc1c1ccccc1

Background Reading

Babu, B.R., and Vaz, A.D.N. 1,2,3-thiadiazole: A novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry 36 7209-7216 (1997).
Size Price Quantity Subtotal
250 mg $11.00 $0.00
500 mg $21.00 $0.00
1 g $40.00 $0.00
5 g $176.00 $0.00
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Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Related Products

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4-phenyl-1,2,3-Thiadiazole

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