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KB2115 Exclusive

Cayman Chemical Item Number 10011054

(CAS 355129-15-6)

KB2115 (CAS 355129-15-6)

See more	Atherosclerosis (323) Obesity (162)

Description

The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), promote the reduction of plasma cholesterol levels and induce weight loss. However when administered in high doses, thyroid hormones produce undesirable side effects in the heart, bone and muscle. KB2115 is a synthetic thyroid hormone mimetic. At a dose of 50-200 µg administered to humans once-daily for 14 days, KB2115 lowers total and LDL cholesterol up to 40% without affecting HDL cholesterol levels and without deleterious side effects to the cardiovascular system.¹ Unlike the statin class of drugs which decrease cholesterol synthesis, KB2115 stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.¹

1 Berkenstam, A., Kristensen, J., Mellström, K., et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci USA 105(2) 663-667 (2008).

Formal Name	3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)phenoxy]phenyl]amino-3-oxo-propanoic acid
CAS Number	355129-15-6
Molecular Formula	C₁₈H₁₇Br₂NO₅
Formula Weight	487.1
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC(=O)CC(=O)Nc1cc(Br)c(Oc2ccc(O)c(c2)C(C)C)c(Br)c1

Background Reading

Berkenstam, A., Kristensen, J., Mellström, K., et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci USA 105(2) 663-667 (2008).

Size	Price	Quantity	Subtotal
500 µg	$25.00		$0.00
1 mg	$48.00		$0.00
5 mg	$200.00		$0.00
10 mg	$350.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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