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4-phenyl-1,2,3-Thiadiazole

Cayman Chemical Item Number 10011055

NSC 111906 (CAS 25445-77-6)

4-phenyl-1,2,3-Thiadiazole (CAS 25445-77-6)

See more	Kit Component (1065)

Description

Cytochrome P450 (CYP450) enzymes are a superfamily of oxidative catalysts important in the biosynthesis and metabolism of a wide range of endogenous molecules as well as the metabolism of xenobiotics. For example, CYP2B4 metabolizes substituted amines, CYP2E1 metabolizes various alcohols and halogenated alkenes, and CYP1A2 catalyzes the oxygenation of aromatic compounds and polycyclic hydrocarbons. 4-phenyl-1,2,3-Thiadiazole is, at 100 µM, a selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner.¹ 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-1,2,3-thiadiazole, are also commonly used as fungicides, herbicides, and plant growth regulators.

1 Babu, B.R., and Vaz, A.D.N. 1,2,3-thiadiazole: A novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry 36 7209-7216 (1997).

Synonyms	NSC 111906
Formal Name	4-phenyl-1,2,3-thiadiazole
CAS Number	25445-77-6
Molecular Formula	C₈H₆N₂S
Formula Weight	162.2
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard c1ccc(cc1)c1csnn1

Background Reading

Babu, B.R., and Vaz, A.D.N. 1,2,3-thiadiazole: A novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry 36 7209-7216 (1997).

Size	Price	Quantity	Subtotal
250 mg	$17.00		$0.00
500 mg	$32.00		$0.00
1 g	$61.00		$0.00
5 g	$272.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Related Products

2,3-dihydrothieno-Thiadiazole Carboxylate

4,5-diphenyl-1,2,3-Thiadiazole

4-phenyl-5-methyl-1,2,3-Thiadiazole

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