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Clobenpropit (hydrobromide)

Cayman Chemical Item Number 10011126

Carbamimidothioic Acid; VUF-9153 (CAS 145231-35-2)

Clobenpropit (hydrobromide) (CAS 145231-35-2)

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Description

Clobenpropit dihydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier; inhibits histamine binding in rat brain with an ED50 value of 10.5 mg/kg; protects cultured cortical neurons from NMDA-induced excitotoxicity by stimulating GABA release; in mice and rats protects against kindled seizures through its effects on histamine and GABA.
Synonyms
  • Carbamimidothioic Acid
  • VUF-9153
Formal Name N-​[(4-​chlorophenyl)methyl]-​3-​(1H-​imidazol-​5-​yl)propyl ester,​ carbamimidothioic acid,​ dihydrobromide
CAS Number 145231-35-2
Molecular Formula C14H17ClN4S · 2HBr
Formula Weight 470.7
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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N=C(SCCCc1cnc[nH]​1)​NCc1ccc(Cl)​cc1

Background Reading

Dai, H., Fu, Q., Shen, Y., et al. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol 563 117-123 (2007).

Barnes, J.C., Brown, J.D., Clarke, N.P., et al. Pharmacological activity of VUF 9153, an isothiourea histamine H3 receptor antagonist. Eur J Pharmacol 250 147-152 (1993).

Harada, C., Fujii, Y., Hirai, T., et al. Inhibitory effect of iodophenprofit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Res Bull 63 143-146 (2004).
Size Price Quantity Subtotal
1 mg $28.00 $0.00
5 mg $126.00 $0.00
10 mg $224.00 $0.00
25 mg $490.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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