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Clobenpropit (hydrobromide)

Cayman Chemical Item Number 10011126

Carbamimidothioic Acid; VUF-9153 (CAS 145231-35-2)

Clobenpropit (hydrobromide) (CAS 145231-35-2)

See more	Receptor Antagonist (45) Neuroscience (654)

Description

Clobenpropit dihydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier; inhibits histamine binding in rat brain with an ED₅₀ value of 10.5 mg/kg; protects cultured cortical neurons from NMDA-induced excitotoxicity by stimulating GABA release; in mice and rats protects against kindled seizures through its effects on histamine and GABA.

Synonyms	Carbamimidothioic Acid VUF-9153
Formal Name	N-[(4-chlorophenyl)methyl]-3-(1H-imidazol-5-yl)propyl ester, carbamimidothioic acid, dihydrobromide
CAS Number	145231-35-2
Molecular Formula	C₁₄H₁₇ClN₄S · 2 HBr
Formula Weight	470.7
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N=C(SCCCc1cnc[nH]1)NCc1ccc(Cl)cc1

Background Reading

Barnes, J.C., Brown, J.D., Clarke, N.P., et al. Pharmacological activity of VUF 9153, an isothiourea histamine H3 receptor antagonist. Eur J Pharmacol 250 147-152 (1993).

Harada, C., Fujii, Y., Hirai, T., et al. Inhibitory effect of iodophenprofit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Res Bull 63 143-146 (2004).

Dai, H., Fu, Q., Shen, Y., et al. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol 563 117-123 (2007).

Size	Price	Quantity	Subtotal
1 mg	$28.00		$0.00
5 mg	$126.00		$0.00
10 mg	$224.00		$0.00
25 mg	$490.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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