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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Thioperamide Maleate

Cayman Chemical Item Number 10011127

(CAS 148440-81-7)

Thioperamide Maleate (CAS 148440-81-7)

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Description

Thioperamide maleate is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.1 At a dose of 5 mg/kg thioperamide maleate inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.2

1 Meir, G., Apelt, J., Reichert, U., et al. Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonists. Eur J Pharm Sci 13 249-259 (2001).

2 Harada, C., Fujii, Y., Hirai, T., et al. Inhibitory effect of iodophenprofit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Res Bull 63 143-146 (2004).

Formal Name N-​cyclohexyl-​4-​(1H-​imidazol-​5-​yl)-​(2Z)-​2-​butenedioate-​1-​piperidinecarbothioamide
CAS Number 148440-81-7
Molecular Formula C15H24N4S · C4H4O4
Formula Weight 408.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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S=C(NC1CCCCC1)​N(CC2)​CCC2C3=CN=CN3.O=C(/C=C\C(O)​=O)​O

Background Reading

Thurmond, R.L., Gelfand, E.W., and Dunford, P.J. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat Rev Drug Discov 7 41-53 (2008).
Size Price Quantity Subtotal
1 mg $10.00 $0.00
5 mg $45.00 $0.00
10 mg $80.00 $0.00
25 mg $175.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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