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BAY-60-7550

Cayman Chemical Item Number 10011135

(CAS 439083-90-6)

BAY-60-7550 (CAS 439083-90-6)

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Description

The second messengers cAMP and cGMP are important mediators of signal transduction and hence a wide range of cellular processes including vasodilation and synaptic plasticity. Type 2 cyclic nucleotide phosphodiesterases (PDE2) isoforms inactivate cAMP and cGMP by hydrolyzing the phosphodiester bond. BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).1 It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.1 At 3 mg/kg BAY-60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling.2 At 1 mg/kg BAY-60-7550 improves the performance of rats in an object location task, enhancing cAMP/cGMP-mediated object and spatial memory consolidation.3

1 Boess, F.G., Hendrix, M., van der Staay, F., et al. Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology 47 1081-1092 (2004).

2 Masood, A., Nadeem, A., Mustafa, S.J., et al. Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. J Pharmacol Exp Ther 326(2) 369-379 (2008).

3 Rutten, K., Van Donkelaar, E.L., Ferrington, L., et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology (2009).

Formal Name 2-​[(3,​4-​dimethoxyphenyl)methyl]-​7-​[(1R)-​1-​hydroxyethyl]-​4-​phenylbutyl]-​5-​methyl-​imidazo[5,​1-​f][1,​2,​4]triazin-​4(1H)-​one
CAS Number 439083-90-6
Molecular Formula C27H32N4O4
Formula Weight 476.6
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1cc(ccc1OC)​Cc1[nH]​c(=O)​c2c(C)​nc([C@@H]​(CCCc3ccccc3)​[C@@H]​(C)​O)​n2n1

Background Reading

Boess, F.G., Hendrix, M., van der Staay, F., et al. Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology 47 1081-1092 (2004).

Rutten, K., Van Donkelaar, E.L., Ferrington, L., et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology (2009).

Masood, A., Nadeem, A., Mustafa, S.J., et al. Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. J Pharmacol Exp Ther 326(2) 369-379 (2008).

Size Price Quantity Subtotal
1 mg $75.00 $0.00
5 mg $338.00 $0.00
10 mg $600.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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