Cayman Chemical | WWL70 | Description (CAS 947669-91-2)

10011213 WWL70

(CAS 947669-91-2)

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α/β-Hydrolase domain 6 (ABHD6) is a serine hydrolase that is highly expressed in mammalian brain. This enzyme catalyzes the hydrolysis of the endocannabinoid 2-arachidonoyl glycerol (2-AG).¹ WWL70 is a selective inhibitor of ABHD6 with an IC₅₀ value of 70 nM.²

1 Blankman, J.L., Simon, G.M., Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & Biology 14 1347-1356 (2007).

2 Li, W., Blankman, J.L., Cravatt, B.F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. Journal of American Chemical Society 129 9594-9595 (2007).

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Pricing updated 2010-03-16.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.