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WWL70 Exclusive

Cayman Chemical Item Number 10011213

(CAS 947669-91-2)

WWL70 (CAS 947669-91-2)

See more	Inhibitors (493) Neuroscience (654)

Description

α/β-Hydrolase domain 6 (ABHD6) is a serine hydrolase that is highly expressed in mammalian brain. This enzyme catalyzes the hydrolysis of the endocannabinoid 2-arachidonoyl glycerol (2-AG).¹ WWL70 is a selective inhibitor of ABHD6 with an IC₅₀ value of 70 nM.²

1 Blankman, J.L., Simon, G.M., and Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol 14 1347-1356 (2007).

2 Li, W., Blankman, J.L., and Cravatt, B.F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J Am Chem Soc 129 9594-9595 (2007).

Formal Name	N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester, carbamic acid
CAS Number	947669-91-2
Molecular Formula	C₂₇H₂₃N₃O₃
Formula Weight	437.5
Formulation	A crystalline solid
Purity	>97%
λ_max	203, 266 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(Oc1ccc(cc1)c1ccc(cc1)C(=O)N)N(C)Cc1cccc(c1)c1ccncc1

Background Reading

Blankman, J.L., Simon, G.M., and Cravatt, B.F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol 14 1347-1356 (2007).

Li, W., Blankman, J.L., and Cravatt, B.F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J Am Chem Soc 129 9594-9595 (2007).

Size	Price	Quantity	Subtotal
1 mg	$36.00		$0.00
5 mg	$162.00		$0.00
10 mg	$288.00		$0.00
25 mg	$630.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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