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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

β-Defensin-2 (human recombinant)

Cayman Chemical Item Number 10011217

hBD-2; Antimicrobial Peptide

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Description

Source: Recombinant protein purified from E. coli · Mr: 4.6 kDa · The β-defensins are small, cysteine-rich, cationic peptides expressed throughout the epithelia of many organs. Expression of these defensin genes is regulated in response to infection and inflammation. β-defensins play important roles along with α-defensins in the human primary defense system against infection. They have been reported to link innate and adaptive immunity by attracting immature dendritic cells and memory T-cells. The antimicrobial, antiviral, and immunomodulatory properties of β-defensins increase resistance to infection.1,2 Due to their unique mechanism of action, β-defensins are expected to be ideal therapeutic agents as peptide antibiotics, mitigating the problem of acquired resistance. Cayman’s β-defensin is a human recombinant protein expressed and purified from E. coli.3,4

1 Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415 389-395 (2002).

2 Lehrer, R.I. Multispecific myeloid defensins. Curr Opin Hematol 14 16-21 (2007).

3 Fang, X., Peng, L., Xu, Z., et al. Cloning and expression of human beta-defensin-2 gene in Escherichia coli. Protein Pept Lett 9(1) 31-37 (2002).

4 Xu, Z., Peng, L., Zhong, Z., et al. High-level expression of a soluble functional antimicrobial peptide, human β-defensin 2, in Escherichia coli. Biotechnol Prog 22(2) 382-386 (2006).

Synonyms
  • hBD-2
  • Antimicrobial Peptide
Formulation 50 mM Tris HCl, pH 8.0, containing 500 mM sodium chloride and 20% glycerol
Purity ≥90%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415 389-395 (2002).

Lehrer, R.I. Multispecific myeloid defensins. Curr Opin Hematol 14 16-21 (2007).

Xu, Z., Peng, L., Zhong, Z., et al. High-level expression of a soluble functional antimicrobial peptide, human β-defensin 2, in Escherichia coli. Biotechnol Prog 22(2) 382-386 (2006).

Fang, X., Peng, L., Xu, Z., et al. Cloning and expression of human beta-defensin-2 gene in Escherichia coli. Protein Pept Lett 9(1) 31-37 (2002).

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Size Price Quantity Subtotal
5 µg $122.00 $0.00
10 µg $232.00 $0.00
25 µg $549.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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