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Protein Phosphatase 2A C subunit (human recombinant; L309 deletion) Exclusive

Cayman Chemical Item Number 10011237

PP2A Cα; PP2A Δ³⁰⁹; PP2A L309

See more	Enzyme Activity (146) Enzymes (119) Phosphatases (4) Proteins (180) Recombinant Proteins (171) Cancer (606) Cell Biology (281) Cell Cycle (71) Signal Transduction (314) Toxicology (23)

Description

Source: Human recombinant PP2A catalytic subunit · M_r: 38.6 kDa · Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also thought to be a potential tumor suppressor.¹ PP2A is a hetrotrimeric protein containing a 65 kDa scaffolding A subunit, a regulatory B subunit and a 36-kDa catalytic C subunit.² The recombinant PP2A catalytic subunit has the characteristic properties of Type 2A phosphatases and is highly sensitive to okadaic acid and microcystins.³ The provided preparation of the catalytic subunit of PP2A is useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and to evaluate the effects of test substances on the activity of the phosphatase.

1 Perrotti, D., and Neviani, P. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer Metastasis Rev (2008).

2 Xing, Y., Xu, Y., Chen, Y., et al. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell 127 341-353 (2006).

3 Ikehara, T., Shinjo, F., Ikehara, S., et al. Baculovirus expression, purification, and characterization of human protein phosphatase 2A catalytic subunits α and β. Protein Expr Purif 45(1) 150-156 (2006).

Synonyms	PP2A Cα PP2A Δ309 PP2A L309
Formulation	20 mM Tris-HCl, pH 7.5, containing 100 mM sodium chloride, 1 mM EDTA, 1 mM DTT, 5 mM MgCl2, and 25% glycerol
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere

Background Reading

Perrotti, D., and Neviani, P. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer Metastasis Rev (2008).

Ikehara, T., Shinjo, F., Ikehara, S., et al. Baculovirus expression, purification, and characterization of human protein phosphatase 2A catalytic subunits α and β. Protein Expr Purif 45(1) 150-156 (2006).

Xing, Y., Xu, Y., Chen, Y., et al. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell 127 341-353 (2006).

Size	Price	Quantity	Subtotal
5 µg	$122.00		$0.00
10 µg	$232.00		$0.00
50 µg	$976.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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