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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10574

Cayman Chemical Item Number 10011247

(CAS 140651-18-9)

CAY10574 (CAS 140651-18-9)

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Description

Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. CAY10574 is a potent, selective inhibitor of CDK9 in vitro with an IC50 value of 0.35 µM. It is also a competitive inhibitor of CDK2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 µM, respectively.1 CAY10574 reduces the population of S-phase cells of the cancer cell line HT-29 and blocks proliferation of several other cancer cell lines including MCF7, HOS, G361, and K562 cells with IC50 values of 33, 49, 64, and 62 µM, respectively.1

1 Krystof, V., Cankar, P., Frysová, I., et al. 4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem 49 6500-6509 (2006).

Formal Name 4-​[(3,​5-​diamino-​1H-​pyrazol-​4-​yl)azo]-​phenol
CAS Number 140651-18-9
Molecular Formula C9H10N6O
Formula Weight 218.2
Formulation A crystalline solid
Purity >95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1ccc(cc1)​\N=N/c1c(N)​n[nH]​c1N

Background Reading

Krystof, V., Cankar, P., Frysová, I., et al. 4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem 49 6500-6509 (2006).
Size Price Quantity Subtotal
1 mg $19.00 $0.00
5 mg $86.00 $0.00
10 mg $152.00 $0.00
50 mg $665.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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