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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10575

Cayman Chemical Item Number 10011248

(CAS 916985-21-2)

CAY10575 (CAS 916985-21-2)

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Description

The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 µM.1

1 Bamborough, P., Christopher, J.A., Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-e kinase. Bioorg Med Chem Lett 16 6236-6240 (2006).

Formal Name 5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[4-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarboxamide
CAS Number 916985-21-2
Molecular Formula C22H21N3O6S2
Formula Weight 487.6
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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COc1cc2c(ncn2c2cc(OCc3ccc(cc3)​S(=O)​(=O)​C)​c(s2)​C(=O)​N)​cc1OC

Background Reading

Bamborough, P., Christopher, J.A., Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-e kinase. Bioorg Med Chem Lett 16 6236-6240 (2006).

CAY10575 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $25.00 $0.00
5 mg $113.00 $0.00
10 mg $200.00 $0.00
25 mg $438.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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