Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10576

Cayman Chemical Item Number 10011249

(CAS 862812-98-4)

CAY10576 (CAS 862812-98-4)

See more	Inhibitors (493) Immunology (181) Inflammation (383)

Description

The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. CAY10576 is a benzimidazole analog that selectively inhibits IKK-ε with an IC₅₀ value of 40 nM and is essentially inactive at IKK-α and IKK-β.¹

1 Bamborough, P., Christopher, J.A., Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-e kinase. Bioorg Med Chem Lett 16 6236-6240 (2006).

Formal Name	5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
CAS Number	862812-98-4
Molecular Formula	C₂₂H₁₉N₃O₅S₂
Formula Weight	469.5
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CS(C1=C(COC2=C(C#N)SC(N3C=NC4=CC(OC)=C(OC)C=C43)=C2)C=CC=C1)(=O)=O

Background Reading

Bamborough, P., Christopher, J.A., Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-e kinase. Bioorg Med Chem Lett 16 6236-6240 (2006).

CAY10576 is available in the following screening library:

Kinase Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$36.00		$0.00
5 mg	$162.00		$0.00
10 mg	$288.00		$0.00
50 mg	$1,260.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Caffeic Acid phenylethyl ester

CAY10575

NF-κB (human p50/p65) Combo Transcription Factor Assay Kit

NF-κB (human p50) Transcription Factor Assay Kit

NF-κB (p65) Transcription Factor Assay Kit

QNZ

Show all 6 Hide all but first 3

Downloads

	Download Product Insert 135 Kb PDF
	Download Material Safety Data Sheet (MSDS) 19 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640