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TWS119

Cayman Chemical Item Number 10011251

(CAS 601514-19-6)

TWS119 (CAS 601514-19-6)

See more	Inhibitors (546) Cell Cycle (72) Stem Cell Research (23)

Description

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC₅₀ value of 30 nM.¹ At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.¹

1 Ding, S., Wu, T.Y.H., Brinker, A., et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci USA 100(13) 7632-7637 (2003).

Formal Name	3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol
CAS Number	601514-19-6
Molecular Formula	C₁₈H₁₄N₄O₂
Formula Weight	318.3
Formulation	A crystalline solid
Purity	≥90%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Oc1cccc(c1)Oc1ncnc2[nH]c(cc12)c1cccc(N)c1

Background Reading

Ding, S., Wu, T.Y.H., Brinker, A., et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci USA 100(13) 7632-7637 (2003).

Size	Price	Quantity	Subtotal
1 mg	$36.00		$0.00
5 mg	$162.00		$0.00
10 mg	$288.00		$0.00
25 mg	$630.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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