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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

NSC 210902

Cayman Chemical Item Number 10011255

(CAS 51726-83-1)

NSC 210902 (CAS 51726-83-1)

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Description

Casein Kinase 2 (CK2) is a serine/threonine-selective protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. NSC 210902 inhibits CK2 with an IC50 value of 1 µM and competitively inhibits binding of ATP with a Ki value of 0.28 µM.1 NSC 210902 is selective for CK2 as it only minimally inhibits the activities of other protein kinases (e.g., JNK3, GSK3, CDK5, and MSK1).1

1 Golub, A.G., Yakovenko, O.Y., Bdzhola, V.G., et al. Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem 49 6443-6450 (2006).

Formal Name 1,​4-​dihydro-​4-​oxo-​benzo[h]quinoline-​3-​carboxylic acid
CAS Number 51726-83-1
Molecular Formula C14H9NO3
Formula Weight 239.2
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​c1c[nH]​c2c(ccc3ccccc23)​c1=O

Background Reading

Golub, A.G., Yakovenko, O.Y., Bdzhola, V.G., et al. Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem 49 6443-6450 (2006).

NSC 210902 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $13.00 $0.00
5 mg $59.00 $0.00
10 mg $104.00 $0.00
50 mg $455.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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