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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10577

Cayman Chemical Item Number 10011256

(CAS 300675-28-9)

CAY10577 (CAS 300675-28-9)

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Description

Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis and its activity is increased in many proliferating tissues and tumors, which lends promise as an anti-cancer drug target. CAY10577 inhibits CK2 with an IC50 value of 0.8 µM.1

1 Golub, A.G., Yakovenko, O.Y., Bdzhola, V.G., et al. Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem 49 6443-6450 (2006).

Formal Name 7,​8-​dichloro-​1,​4-​dihydro-​4-​oxo-​3-​quinolinecarboxylic acid
CAS Number 300675-28-9
Molecular Formula C10H5Cl2NO3
Formula Weight 258.1
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​c1c[nH]​c2c(Cl)​c(Cl)​ccc2c1=O

Background Reading

Golub, A.G., Yakovenko, O.Y., Bdzhola, V.G., et al. Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem 49 6443-6450 (2006).

CAY10577 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $13.00 $0.00
5 mg $59.00 $0.00
10 mg $104.00 $0.00
50 mg $455.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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CAY10578

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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