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CAY10578

Cayman Chemical Item Number 10011264

(CAS 19231-60-8)

CAY10578 (CAS 19231-60-8)

See more	Inhibitors (546) Apoptosis (191) Cancer (666) Cell Cycle (72) Signal Transduction (328)

Description

Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 with an IC₅₀ value of 0.3 µM.¹ This compound is ATP competitive, displaying a K_i value of 0.2 µM and only minimally inhibits the activities of other protein kinases (e.g., GSK3, CDK5, and MSK1).¹

1 Golub, A.G., Yakovenko, O.Y., Prykhod'ko, A.O., et al. Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochem Biophys Acta 1784 143-149 (2008).

Formal Name	4,5,6,7-tetraiodo-1,3-dioxo-2-isoindolineacetic acid
CAS Number	19231-60-8
Molecular Formula	C₁₀H₃I₄NO₄
Formula Weight	708.8
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC(=O)CN1C(=O)c2c(C1=O)c(I)c(I)c(I)c2I

Background Reading

Golub, A.G., Yakovenko, O.Y., Prykhod'ko, A.O., et al. Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochem Biophys Acta 1784 143-149 (2008).

CAY10578 is available in the following screening library:

Kinase Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$13.00		$0.00
5 mg	$59.00		$0.00
10 mg	$104.00		$0.00
25 mg	$228.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Related Products

CAY10577

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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