p38 MAPK Monoclonal Antibody (Clone 9F12)

Cayman Chemical Item Number 10011301

p38 Mitogen-activated Protein Kinase; p38 MAPKα

Description

Antigen: human full length p38 MAPK · Clone designation: clone 9F12 · Host: mouse · Application(s): WB, ICC, and flow cytometry · p38 mitogen-activated protein kinase (MAPK) is a member of the serine-threonine MAPK family that triggers many cellular processes including cell cycle, development, and apoptosis.^1,2 These kinases are activated by environmental stress signals such as osmotic shock, infection, and cytokines causing phosphorylation of p38 MAPK. This results in a phosphorylation cascade, activating transcription factors, and inducing gene expression.^1,3 p38 MAPK is widely expressed in heart, brain, skeletal muscle, platelets, and immune cells. Due to this distribution, p38 MAPK plays a role in cardiovascular disease, arthritis, and cancer.^2,4,5,3 It is mainly present in the cytosol, but can also be found in the nucleus after activation.² Based on the amino acid sequence, the expected molecular weight of this protein is 41 kDa.

1 Junttila, M.R., Li, S., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008).

2 Dhillon, A.S., Hagan, S., Rath, S., et al. MAP kinase signalling pathways in cancer. Oncogene 26 3279-3290 (2007).

3 Wang, Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 116 1413-1423 (2007).

4 Schett, G., Zwerina, J., and Firestein, G. The p38 mitogen activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis 67 909-916 (2007).

5 Foster, A., Fitzsimmons, B., Rokach, J., et al. Evidence of in vivo ω-oxidation of peptide leukotrienes in the rat: Biliary excretion of 20-CO2H N-acetyl LTE₄. Biochem Biophys Res Commun 148 1237-1245 (1987).

Synonyms

p38 Mitogen-activated Protein Kinase
p38 MAPKα

Formulation

200 µg IgG1 in 500 µl PBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human p38 MAPK	+
Mouse p38 MAPK	+
Rat p38 MAPK	+

Background Reading

Junttila, M.R., Li, S., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008).

Schett, G., Zwerina, J., and Firestein, G. The p38 mitogen activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis 67 909-916 (2007).

Cook, R., Wu, C., Kang, Y.J., et al. The role of the p38 pathway in adaptive immunity. Cell Mol Immunol 4(4) 253-259 (2007).

Wang, Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 116 1413-1423 (2007).

Dhillon, A.S., Hagan, S., Rath, S., et al. MAP kinase signalling pathways in cancer. Oncogene 26 3279-3290 (2007).

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1 ea

$250.00

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