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Avenanthramide-C methyl ester Exclusive

Cayman Chemical Item Number 10011336

(CAS 955382-52-2)

Avenanthramide-C methyl ester (CAS 955382-52-2)

See more	Inhibitors (493) Inflammation (383) Signal Transduction (314)

Description

Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC₅₀ ~ 40 μM).¹ Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells. ¹

1 Guo, W., Wise, M.L., Collins, F.W., et al. Avenanthramides, polyphenols from oats, inhibit IL-1β-induced NF-κB activation in endothelial cells. Free Radic Biol Med 44 415-429 (2008).

Formal Name	2-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]5-hydroxy-benzoic acid, methyl ester
CAS Number	955382-52-2
Molecular Formula	C₁₇H₁₅NO₆
Formula Weight	329.3
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC1=CC(C(OC)=O)=C(NC(/C=C/C2=CC(O)=C(O)C=C2)=O)C=C1

Background Reading

Guo, W., Wise, M.L., Collins, F.W., et al. Avenanthramides, polyphenols from oats, inhibit IL-1β-induced NF-κB activation in endothelial cells. Free Radic Biol Med 44 415-429 (2008).

Size	Price	Quantity	Subtotal
500 µg	$43.00		$0.00
1 mg	$82.00		$0.00
5 mg	$344.00		$0.00
10 mg	$602.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

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