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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Dimebolin (hydrochloride)

Cayman Chemical Item Number 10011349

(CAS 97657-92-6)

Dimebolin (hydrochloride) (CAS 97657-92-6)

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Description

Dimebolin (hydrochloride), also known as Dimebon™, is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s disease and Huntington’s disease. 1,2,3 In addition to preventing the onset and progression of disease by being neuroprotective, Dimebolin appears to promote clinical improvement by increasing cognitive function.4,2 At the cellular level, Dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and blocking L-type calcium channels, inhibiting NMDA-type glutamate receptors, and preventing mitochondrial leakage.5,6,7 The hydrochloride form of Dimebolin is soluble in both aqueous and organic solvents.

1 Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. Bull Exp Biol Med 129(6) 640-642 (2000).

2 Doody, R.S., Gavrilova, S.I., Sano, M., et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: A randomised, double-blind, placebo-controlled study. Lancet 372 207-215 (2008).

3 Wu, J., Li, Q., and Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Mol Neurodegener 3(15) (2008).

4 Bachurin, S., Bukatina, E., Lermontova, N., et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 939 425-435 (2001).

5 Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. Bull Exp Biol Med 132(5) 1079-1083 (2001).

6 Grigor'ev, V.V., Dranyi, O.A., and Bachurin, S.O. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136(5) 474-477 (2003).

7 Bachurin, S.O., Shevtsova, E.P., Kireeva, E.G., et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 993 334-344 (2003).

Formal Name 2,​3,​4,​5-​tetrahydro-​2,​8-​dimethyl-​5-​[2-​(6-​methyl-​3-​pyridinyl)ethyl]-​1H-​pyrido[4,​3-​b]indole,​ dihydrochloride
CAS Number 97657-92-6
Molecular Formula C21H25N3 · 2HCl
Formula Weight 392.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CN1CCc2n(CCc3ccc(C)​nc3)​c3ccc(C)​cc3c2C1

Background Reading

Grigor'ev, V.V., Dranyi, O.A., and Bachurin, S.O. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136(5) 474-477 (2003).

Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. Bull Exp Biol Med 129(6) 640-642 (2000).

Doody, R.S., Gavrilova, S.I., Sano, M., et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: A randomised, double-blind, placebo-controlled study. Lancet 372 207-215 (2008).

Wu, J., Li, Q., and Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Mol Neurodegener 3(15) (2008).

Bachurin, S., Bukatina, E., Lermontova, N., et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 939 425-435 (2001).

Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. Bull Exp Biol Med 132(5) 1079-1083 (2001).

Bachurin, S.O., Shevtsova, E.P., Kireeva, E.G., et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 993 334-344 (2003).

Ivanov, Y.Y., Afanas'ev, A.Z., and Bachurin, S.O. Calcium-antagonist activity of some hydrogenated pyrido[4,3-B]indole derivatives. Pharm Chem J 35(7) 353-354 (2001).

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Size Price Quantity Subtotal
1 mg $18.00 $0.00
5 mg $81.00 $0.00
10 mg $126.00 $0.00
25 mg $315.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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