sPLA₂ (human Type IIA) Western Ready Control Exclusive

Cayman Chemical Item Number 10011382

Secretory Phospholipase A₂ (human Type IIA); sPLA₂ (human synovial)

See more	Eicosanoids (216) Phospholipase (79) Proteins (180) Recombinant Proteins (171) Western Ready Control (27) Alzheimer's Research (44) Inflammation (383)

Description

Application(s): positive control for WB · Source: human recombinant protein expressed in E. coli · M_r: 16 kDa · Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of phospholipids at the sn-2 position yielding a free fatty acid and a lysophospholipid.¹ The release of arachidonic acid from the membrane phospholipids by PLA₂ is believed to be a key step in the control of eicosanoid production within the cell.² Human synovial sPLA₂ is a secreted 14 kDa protein which is dependent on Ca2+ for optimal activity. Human synovial sPLA₂ is 79% homologous to rat platelet and murine type II sPLA₂s.

1 Dennis, E.A. Phospholipases. Enzymes XVI 307-353 (1983).

2 Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A₂. J Biol Chem 269 13057-13060 (1994).

Synonyms	Secretory Phospholipase A2 (human Type IIA) sPLA2 (human synovial)
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Dennis, E.A. Phospholipases. Enzymes XVI 307-353 (1983).

Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A₂. J Biol Chem 269 13057-13060 (1994).

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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sPLA2 (human Type IIA) Western Ready Control Exclusive

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sPLA₂ (human Type IIA) Western Ready Control Exclusive