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Bim/BOD (IN) Polyclonal Antibody

Cayman Chemical Item Number 10011385

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Description

Antigen: internal central human Bim amino acids · Host: rabbit · Application(s): WB and IHC · Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse, and rat.1,2 Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.1,2

1 O'Connor, L., Strasser, A., O'Reilly, L.A., et al. Bim: A novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17 384-395 (1998).

2 Hsu, S.Y., Lin, P., and Hsueh, A.J.W. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol 12 1432-1440 (1998).

Formula Weight 23.0
Formulation Immunoaffinity chromatography purified IgG at 1 mg/ml in PBS containing 0.02% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human Bim/BOD (IN) +
Mouse Bim/BOD (IN) +
Rat Bim/BOD (IN) +

Background Reading

O'Connor, L., Strasser, A., O'Reilly, L.A., et al. Bim: A novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17 384-395 (1998).

Hsu, S.Y., Lin, P., and Hsueh, A.J.W. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol 12 1432-1440 (1998).
Size Price Quantity Subtotal
25 µg $112.00 $0.00
100 µg $403.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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