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AL 34662

Cayman Chemical Item Number 10011546

AL 34497 (CAS 210580-75-9)

AL 34662 (CAS 210580-75-9)

See more	Neuroscience (654) Ophthalmology (61)

Description

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated via at least six major 5-HT receptor subtypes, including 5-HT2. AL 34662 is a potent 5-HT2 receptor agonist with ocular hypotensive activity. It binds to the human and rat 5-HT2 receptors in cerebral cortex homogenates with IC₅₀ values of 1.5 and 0.77 nM, respectively.¹ AL 34662 binds to the recombinant human 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC₅₀ values of 14.5, 8.1, and 3 nM, respectively. In ocular hypertensive cynomolgus monkey eyes, AL 34662 lowered intraocular pressure (IOP) 25% at a dose of 100 µg and 33% at 300 µg (six hours post dose) with minimal side effects.¹

1 Sharif, N.A., Mclaughlin, M.A., and Kelly, C.R. AL-34662: A potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther 23(1) 1-13 (2007).

Synonyms	AL 34497
Formal Name	1-[(2S)-2-aminopropyl]-1H-indazol-6-ol
CAS Number	210580-75-9
Molecular Formula	C₁₀H₁₃N₃O
Formula Weight	191.2
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard C[C@H](N)Cn1ncc2ccc(O)cc12

Background Reading

Sharif, N.A., Mclaughlin, M.A., and Kelly, C.R. AL-34662: A potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther 23(1) 1-13 (2007).

Size	Price	Quantity	Subtotal
1 mg	$9.00		$0.00
5 mg	$41.00		$0.00
10 mg	$72.00		$0.00
50 mg	$315.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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