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Terbinafine (hydrochloride)Cayman Chemical Item Number 10011619 (CAS 78628-80-5) 
Terbinafine (hydrochloride) (CAS 78628-80-5)
Description
Terbinafine is an antifungal compound that is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast.1 It is clinically used to treat nail and skin infections, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans).2 At 90-
1 Petranyi, G., Meingassner, J.G., and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob Agents Chemother 31(9) 1365-1368 (1987). 2 Ryder, N.S., and Dupont, M. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem J 230 765-770 (1985).
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Lee, W., Chen, R., Wang, Y., et al. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53- 4 Ho, P., Liang, Y., Ho, Y., et al. Inhibition of human vascular endothelial cells proliferation by terbinafine. Int J Cancer 111 51-59 (2004).
Background ReadingRyder, N.S., and Dupont, M. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem J 230 765-770 (1985). Lee, W., Chen, R., Wang, Y., et al. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53- Petranyi, G., Meingassner, J.G., and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob Agents Chemother 31(9) 1365-1368 (1987). Ho, P., Liang, Y., Ho, Y., et al. Inhibition of human vascular endothelial cells proliferation by terbinafine. Int J Cancer 111 51-59 (2004). Show all 4 Hide all but first 3 |
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