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Terbinafine (hydrochloride)

Cayman Chemical Item Number 10011619

(CAS 78628-80-5)

Terbinafine (hydrochloride) (CAS 78628-80-5)

See more	Inhibitors (493) Angiogenesis (29) Cancer (606) Cell Cycle (71)

Description

Terbinafine is an antifungal compound that is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast.¹ It is clinically used to treat nail and skin infections, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC₅₀ = 30 nM for C. albicans).² At 90-120 µM, terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G₀/G₁ stage in COLO 205 tumor cells and human vascular endothelial cells.^3,4

1 Petranyi, G., Meingassner, J.G., and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob Agents Chemother 31(9) 1365-1368 (1987).

2 Ryder, N.S., and Dupont, M. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem J 230 765-770 (1985).

3 Lee, W., Chen, R., Wang, Y., et al. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G₀/G₁ p53-associated cell cycle arrest. Int J Cancer 106 125-137 (2003).

4 Ho, P., Liang, Y., Ho, Y., et al. Inhibition of human vascular endothelial cells proliferation by terbinafine. Int J Cancer 111 51-59 (2004).

Formal Name	N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine, monohydrochloride
CAS Number	78628-80-5
Molecular Formula	C₂₁H₂₅N · HCl
Formula Weight	327.9
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CN(C\C=C\CCC(C)(C)C)Cc1cccc2ccccc12Cl

Background Reading

Lee, W., Chen, R., Wang, Y., et al. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G₀/G₁ p53-associated cell cycle arrest. Int J Cancer 106 125-137 (2003).

Petranyi, G., Meingassner, J.G., and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob Agents Chemother 31(9) 1365-1368 (1987).

Ho, P., Liang, Y., Ho, Y., et al. Inhibition of human vascular endothelial cells proliferation by terbinafine. Int J Cancer 111 51-59 (2004).

Ryder, N.S., and Dupont, M. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem J 230 765-770 (1985).

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Size	Price	Quantity	Subtotal
100 mg	$59.00		$0.00
250 mg	$140.00		$0.00
500 mg	$266.00		$0.00
1 g	$472.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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