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Trolox

Cayman Chemical Item Number 10011659

6-hydroxy-2,5,7,8-tetramethylchroman-2-Carboxylic Acid (CAS 53188-07-1)

Trolox (CAS 53188-07-1)

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Description

Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays.1,2 In addition, trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging.3,4 Trolox is effective as adjunctive therapy in the treatment of certain cancers.5

1 Cos, P., Hermans, N., Calomme, M., et al. Comparative study of eight well-known polyphenolic antioxidants. J Pharm Pharmacol 55 1291-1297 (2003).

2 Tadolini, B., Juliano, C., Piu, L., et al. Resveratrol inhibition of lipid peroxidation. Free Radic Res 33 105-114 (2000).

3 Jang, H.J., Hwang, S., Cho, K.Y., et al. Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures. Neurosci Lett 443 17-22 (2008).

4 Benedetti, M.G., Foster, A.L., Vantipalli, M.C., et al. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43 882-891 (2008).

5 Diaz, Z., Laurenzana, A., Mann, K.K., et al. Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity. Leukemia 21 2117-2127 (2007).

Synonyms
  • 6-hydroxy-2,5,7,8-tetramethylchroman-2-Carboxylic Acid
Formal Name 3,​4-​dihydro-​6-​hydroxy-​2,​5,​7,​8-​tetramethyl-​2H-​1-​benzopyran-​2-​carboxylic acid
CAS Number 53188-07-1
Molecular Formula C14H18O4
Formula Weight 250.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Cc1c2OC(C)​(CCc2c(C)​c(O)​c1C)​C(=O)​O

Background Reading

Cos, P., Hermans, N., Calomme, M., et al. Comparative study of eight well-known polyphenolic antioxidants. J Pharm Pharmacol 55 1291-1297 (2003).

Tadolini, B., Juliano, C., Piu, L., et al. Resveratrol inhibition of lipid peroxidation. Free Radic Res 33 105-114 (2000).

Jang, H.J., Hwang, S., Cho, K.Y., et al. Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures. Neurosci Lett 443 17-22 (2008).

Benedetti, M.G., Foster, A.L., Vantipalli, M.C., et al. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 43 882-891 (2008).

Diaz, Z., Laurenzana, A., Mann, K.K., et al. Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity. Leukemia 21 2117-2127 (2007).

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Size Price Quantity Subtotal
50 mg $13.00 $0.00
100 mg $25.00 $0.00
250 mg $59.00 $0.00
500 mg $104.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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