Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Soluble Epoxide Hydrolase (mouse recombinant) Exclusive

Cayman Chemical Item Number 10011670

sEH; Epoxide Hydrolase 2; EPHX2; Cytosolic Epoxide Hydrolase; CEH

Soluble Epoxide Hydrolase (mouse recombinant)

See more	Enzyme Activity (146) Enzymes (119) Proteins (180) Recombinant Proteins (171) Endocrinology (335) Hypertension (90) Inflammation (383)

Description

Source: Mouse recombinant N-terminal His-tagged protein purified from Sf21 cells · M_r: 64 kDa · Mammalian soluble epoxide hydrolase (sEH) is a member of the α/β-hydrolase fold family of enzymes that catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains.¹ The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory effects as well as for their anti-inflammatory actions.² Inhibition of sEH in animal models was shown to reduce hypertension and vascular inflammation, as well as related syndromes, validating sEH as a highly promising target for drug discovery.³

1 Chiamvimonvat, N., Ho, C., Tsai, H., et al. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol 50(3) 225-237 (2007).

2 Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).

3 Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

Synonyms	sEH Epoxide Hydrolase 2 EPHX2 Cytosolic Epoxide Hydrolase CEH
Formulation	TBS buffer at pH 7.4 with 20% glycerol
Purity	≥95%
Stability	6 months
Storage	-80°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).

Chiamvimonvat, N., Ho, C., Tsai, H., et al. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol 50(3) 225-237 (2007).

Wolf, N.M., Morisseau, C., Jones, P.D., et al. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem 355 71-80 (2006).

Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem 343 66-75 (2005).

Show all 5 Hide all but first 3

Size	Price	Quantity	Subtotal
25 µg	$153.00		$0.00
50 µg	$291.00		$0.00
100 µg	$551.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

AUDA Exclusive

CUDA Exclusive

Epoxy Fluor 7 Exclusive

PHOME Exclusive

S-NEPC Exclusive

Soluble Epoxide Hydrolase Blocking Peptide

Soluble Epoxide Hydrolase (human recombinant)

Soluble Epoxide Hydrolase Inhibitor Screening Assay Kit

Soluble Epoxide Hydrolase Polyclonal Antibody

Show all 9 Hide all but first 3

Downloads

	Download Product Insert 183 Kb PDF
	Download Material Safety Data Sheet (MSDS) 23 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640