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ent-8-iso Prostaglandin F_2α-d₉ Exclusive

Cayman Chemical Item Number 10011721

ent-8-epi PGF_2α-d₉; ent-15-F2t-Isoprostane-d₉; ent-8-iso PGF_2α-d₉

ent-8-iso Prostaglandin F2α-d9

See more	Mass Spectrometry (253) Isoprostanes (34) Prostaglandins (513) Oxidative Injury (258)

Description

ent-8-iso-Prostaglandin F_2α-d₉ (ent-8-iso-PGF_2α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19',20,20, and positions. It is intended for use as an internal standard for the quantification of ent-8-iso-PGF_2α by GC- or LC-mass spectrometry. Isoprostanes are produced by the non-enzymatic, free-radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have a potent biological activity. ent-8-iso Prostaglandin F_2α (ent-8-iso PGF_2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC₅₀ values of 31 and 54 nM, respectively.¹

1 Hou, X., Robers, L.J.I., Gobeil, F., et al. Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculature. Free Radic Biol Med 36(2) 163-172 (2004).

Synonyms	ent-8-epi PGF2α-d9 ent-15-F2t-Isoprostane-d9 ent-8-iso PGF2α-d9
Formal Name	9β,11β,15R-trihydroxy-(12α)-prosta-5Z,13E-dien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid
Molecular Formula	C₂₀H₂₅D₉O₅
Formula Weight	363.5
Formulation	A solution in acetonitrile
Purity	≥99% deuterated product
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@@H](O)/C=C/C1[C@@H](O)C[C@@H](O)C1C/C=C\CCCC(=O)O

Background Reading

Hou, X., Robers, L.J.I., Gobeil, F., et al. Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculature. Free Radic Biol Med 36(2) 163-172 (2004).

Size	Price	Quantity	Subtotal
10 µg	$123.00		$0.00
25 µg	$292.00		$0.00
50 µg	$554.00		$0.00
100 µg	$984.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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ent-8-iso Prostaglandin F_2α

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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

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ent-8-iso Prostaglandin F2α-d9 Exclusive