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Propenyl-L-NIO (hydrochloride) Exclusive

Cayman Chemical Item Number 10011724

ENIPO

Propenyl-L-NIO (hydrochloride)

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Description

Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics.1 However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS or eNOS. This selectivity results from iNOS exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS.1 Ki values for ENIPO binding to iNOS and nNOS are 0.56 and 6 µM, respectively.1 Accurate determination of the Ki value of ENIPO for eNOS has not been determined but is expected to be 50-fold less than iNOS.1

1 Bretscher, L.E., Li, H., Poulos, T.L., et al. Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. J Biol Chem 278(47) 46789-46797 (2003).

Synonyms
  • ENIPO
Formal Name N5-​[(3E)-​1-​imino-​3-​pentenyl]-​L-​ornithine,​ monohydrochloride
Molecular Formula C10H19N3O2 · HCl
Formula Weight 249.7
Formulation A crystalline solid
Purity ≥90%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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C/C=C/CC(=N)​NCCC[C@H]​(N)​C(=O)​O

Background Reading

Bretscher, L.E., Li, H., Poulos, T.L., et al. Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. J Biol Chem 278(47) 46789-46797 (2003).
Size Price Quantity Subtotal
5 mg $51.00 $0.00
10 mg $97.00 $0.00
25 mg $230.00 $0.00
50 mg $408.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

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Methyl-L-NIO (hydrochloride)
Vinyl-L-NIO (hydrochloride)
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